HCG vs. Gonadorelin
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Both HCG and gonadorelin are used in TRT protocols to maintain testicular function — but they work through different mechanisms and have different practical considerations.
HCG mimics LH directly at the testes, while gonadorelin acts at the pituitary to stimulate LH and FSH release. Both maintain testicular function during TRT, but gonadorelin provides a more complete hormonal signal by preserving FSH as well.
Side-by-Side Comparison
| Feature | HCG | Gonadorelin |
|---|---|---|
| Mechanism | LH mimic — acts directly at testes | GnRH analogue — acts at pituitary |
| FSH stimulation | Limited | Yes |
| Dosing frequency | 2–3x per week | 2x per week (pulsatile) |
| Availability | Regulated — compounded HCG | Compounded peptide |
Common Questions
Why was HCG harder to get after 2020?
The FDA reclassified certain compounded HCG products, affecting compounding pharmacy availability. This led many providers to transition patients to gonadorelin as an alternative.
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Medical Disclaimer: The information on this page is provided for educational purposes only and does not constitute medical advice. OakMD is a telemedicine platform. All treatments are prescription-based, subject to provider review, and may not be appropriate for all individuals. A licensed provider will evaluate your medical history and determine eligibility. Consult a qualified healthcare professional before starting any new treatment.