Tadalafil + Sildenafil Combination
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A compounded preparation pairing a long-acting and a short-acting PDE5 inhibitor in a single tablet — designed to combine the steady baseline of tadalafil with the rapid onset of sildenafil.
Tadalafil 20mg / Sildenafil 70mg
Provider-reviewed. Direct-pay, no insurance hassle.
What Is Tadalafil/Sildenafil Combo?
The tadalafil/sildenafil combination is a compounded oral preparation that combines two PDE5 inhibitors. Tadalafil has a half-life of roughly 17.5 hours and is sometimes used as a daily, low-dose baseline; sildenafil has a half-life of about 4 hours and is typically used as needed before activity. Compounding them aims to provide both characteristics in a single dose form.
What It May Help With
This combination is used for adult men with erectile dysfunction who want the duration of tadalafil paired with the rapid onset of sildenafil. Like any PDE5 therapy, it requires provider evaluation to confirm appropriateness and screen for interactions.
Who May Be a Candidate
Most adult men with ED who do not have contraindications to PDE5 inhibitors are potential candidates. Men taking nitrates (for chest pain), certain alpha blockers, or with significant cardiovascular disease should not take PDE5 inhibitors without specialist input. Your OakMD provider will review your full health profile before prescribing.
How OakMD Works
OakMD is a telemedicine platform connecting eligible adults with licensed providers. If you're interested in Tadalafil/Sildenafil Combo, the process begins with a brief online intake form. A licensed provider will review your health history, symptoms, and goals — and determine if treatment is appropriate for you.
If you are a candidate, your provider will create a personalized treatment plan and guide you through next steps. There are no in-person visits required.
Common Questions
How is this combination dosed?
Dosing is set by your provider. Many users take it as needed before activity rather than daily. Do not double-dose if you already take a PDE5 inhibitor separately.
What are the most common side effects?
Headache, flushing, nasal congestion, and indigestion are the most commonly reported effects with PDE5 inhibitors. Tadalafil is more commonly associated with back or muscle aches. Severe side effects are rare but should be discussed with your provider.
Ready to Get Started?
Complete a brief online intake. A licensed provider will review your information and determine if treatment is appropriate for you.
Medical Disclaimer: The information on this page is provided for educational purposes only and does not constitute medical advice. OakMD is a telemedicine platform. All treatments are prescription-based, subject to provider review, and may not be appropriate for all individuals. A licensed provider will evaluate your medical history and determine eligibility. Consult a qualified healthcare professional before starting any new treatment.
Three Steps to Start
Complete your order
Choose your plan, share basic health information at checkout, and place your order.
Provider review
A licensed provider reviews your information and approves a personalized plan.
Receive your medication
Your medication is shipped discreetly to your door from a licensed pharmacy, with ongoing care messaging available.
About This Program
How does the combination work?
Both medications inhibit PDE5 and increase blood flow to the penis through cGMP. The combination pairs the long-acting baseline of tadalafil with the rapid onset of sildenafil.
Is this a compounded medication?
Yes. The combo is dispensed by a licensed compounding pharmacy under provider supervision.
How is it dosed?
Dosing depends on your provider’s protocol. Many users take it as needed before activity rather than daily.
Prescription treatments are subject to provider review. Not all individuals are candidates for treatment. OakMD does not bill insurance directly. Compounded medications are dispensed by licensed compounding pharmacies.